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Hyperpigmentation: Causes, Treatments, and Medication Effects

When your skin develops dark patches that don’t fade, you’re dealing with hyperpigmentation, a condition where excess melanin builds up in certain areas of the skin, creating uneven coloration. Also known as skin discoloration, it’s not just a cosmetic issue—it can be a sign of deeper reactions, from sun damage to how your body processes certain drugs. This isn’t just about aging or freckles. It’s often tied to inflammation, hormones, or the medications you take every day.

One common type is post-inflammatory hyperpigmentation, dark spots that remain after acne, eczema, or even a minor cut heals. It’s more noticeable in people with darker skin tones and can last months—even years—if not treated right. Then there’s melasma, a stubborn form linked to hormones, often triggered by pregnancy, birth control pills, or hormone therapy. And don’t overlook medication-induced pigmentation, where drugs like antibiotics, antidepressants, or chemotherapy agents cause your skin to darken over time. Some of these reactions are rare, but they’re real—and often missed by doctors who focus on the primary condition, not the side effect.

What makes this tricky is that treatments for hyperpigmentation aren’t one-size-fits-all. Topical creams with hydroquinone, retinoids, or vitamin C can help, but they won’t fix the root cause if you’re still taking a drug that’s triggering it. Sunscreen isn’t optional—it’s mandatory. UV exposure makes every dark spot worse, no matter the cause. And while laser treatments sound appealing, they can backfire if your skin is sensitive or if you’re on certain medications. The key is figuring out what’s driving the pigmentation before you start treating the symptom.

You’ll find posts here that dig into how common drugs—like antibiotics, antidepressants, and even supplements—can change your skin’s color. You’ll see what actually works in reducing dark spots, what doesn’t, and how to talk to your doctor when your skin starts acting up. There’s no magic cream that fixes everything, but there are smart, science-backed steps you can take to protect your skin and get clarity. What you’re about to read isn’t just about beauty—it’s about understanding how your body reacts to what you put into it, and how to take control before the spots get worse.